منابع مشابه
Microtubules regulate focal adhesion dynamics through MAP4K4.
Disassembly of focal adhesions (FAs) allows cell retraction and integrin detachment from the extracellular matrix, processes critical for cell movement. Growth of microtubules (MTs) can promote FA turnover by serving as tracks to deliver proteins essential for FA disassembly. The molecular nature of this FA "disassembly factor," however, remains elusive. By quantitative proteomics, we identifie...
متن کاملShRNA-targeted MAP4K4 inhibits hepatocellular carcinoma growth.
PURPOSE Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) is overexpressed in many types of cancer. Herein, we aimed to investigate its expression pattern, clinical significance, and biological function in hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN MAP4K4 expression was examined in 20 fresh HCCs and corresponding nontumor liver tissues. Immunohistochemistry for MAP4K4 ...
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Skeletal muscle is a complicated and heterogeneous striated muscle tissue that serves critical mechanical and metabolic functions in the organism. The process of generating skeletal muscle, myogenesis, is elaborately coordinated by members of the protein kinase family, which transmit diverse signals initiated by extracellular stimuli to myogenic transcriptional hierarchy in muscle cells. Mitoge...
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Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), which has been implicated in inflammation, is abundantly expressed in ECs and in atherosclerotic plaques from mice and hu...
متن کاملRole of Protein Kinase Map4k4 in Energy Metabolism: A Dissertation
The signature of the Dean of the Graduate School of Biomedical Sciences signifies that the student has met all graduation requirements of the school. iii Acknowledgements I'm very fortunate to be surrounded by family, friends, and colleagues that are supportive and encouraging and from whom I constantly learn so much. Thanks to Mike Czech, my graduate mentor, for giving me the opportunity to jo...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2019
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehz365